Monophasic action potentials detect cardiac repolarization times: a Bidomain - LR1 simulation study in 3D
L. F. Pavarino (Dipartimento di Matematica, Università degli Studi di Milano, Italy), P. Colli Franzone (Dipartmento di Matematica, Università degli Studi di Pavia, Italy), S. Scacchi (Dipartmento di Matematica, Università degli Studi di Pavia, Italy) and B. Taccardi (Cardiovascular Research and Training Institute, University of Utah, USA)
We present 3D numerical simulations results obtained with the anisotropic cardiac Bidomain-Luo-RudyI model in presence of strong APD heterogeneity. EGs, transmembrane action potentials (TAPs), and monophasic action potentials (MAPs) elicited by an epicardial stimulation close or away from a permanently depolarized site were computed. The repolarization times were computed as the instant of EG fastest upstroke during the T-wave, of MAP fastest downstroke, and of TAP fastest downstroke. The latter was taken as the gold standard for repolarization time, while the formers are the only proposed extracellular recordings for recovery mapping. For all explored sites, the MAP downstroke closely follows the TAP downstroke and the MAP and TAP repolarization markers are highly correlated. Hence, the MAP downstroke phase, as the EG T-wave, contains valuable information for assessing repolarization times.
References:
- P. Colli Franzone, L. F. Pavarino. S. Scacchi. B. Taccardi.
Monophasic action potentials generated by bidomain modeling as a tool for detecting
cardiac repolarization times, Amer. J. Physiol. Heart Circ. Physiol. 293: H2771-H2785, 2007.
- P. Colli Franzone, L. F. Pavarino. S. Scacchi. B. Taccardi.
Determining Recovery Times from Transmembrane Action Potentials and Unipolar Electrograms in Normal Heart Tissue, in FIMH07, F. Sachse and G. Seemann, Eds.,
LNCS 4466, Springer, 2007.